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The strikingly abnormal neurodevelopment and lethality in Drp1 knockout mice cautions about the consequences of preventing mitochondrial fission.
We have further analysed the consequences of preventing TCR down-modulation, in vitro and in vivo in two very different disease models; antigen-specific inflammatory arthritis and a T cell-derived lymphoma.
1) Risk-reframing teachers and parents will participate together in small group intervention sessions focusing on the benefits of manageable risk-taking (including vigilance and taking increasingly greater responsibility for one's own actions), the consequences of preventing children from engaging in manageable risk-taking, and strategies for making everyday risks manageable.
In order to gain experimental evidence of the pathological significance of Ataxin-3 protein cleavage in vivo, we used the fruit fly model system to define potential cleavage of the Ataxin-3 protein in the nervous system in vivo, and the consequences of preventing that cleavage pattern.
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"And the main consequence of preventing the most dynamic members of society from getting rich is to make everyone else poor".
"It is a fine line to walk between protecting consumers and doing something that has the unintended consequence of preventing responsible lending," Sandra Braunstein, who oversees consumer issues at the Fed, told me yesterday.
This reduction may have the consequence of preventing irrelevant information from entering WM, thereby protecting its contents from interference [33],[33].
Inhibition of splicing might be a consequence of preventing the Cap-binding complex to bind, which, in turn, can recruit the spliceosome.
The encapsulation of fluorescent markers makes it possible to offer more advantages in comparison to free photo-dependent active agent as a consequence of preventing the delocalization of its molecules and overcoming serious side effects after light excitation.
To test whether YFP-PrP∗ aggregation in Tmp21 knockdown cells was simply a consequence of preventing this exit, we analyzed control cells subjected to ER stress in the presence of BFA to prevent ER export.
Unexpectedly, the srs2-K41A, srs2-K41R and srs2 875Δ 902 mutants fail to suppress the rad18 sensitivity to UV irradiation, indicating that the sensitivity of rad18Δ mutants is not a consequence of preventing recombinational repair.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com