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To evaluate the functional consequences of manipulation of ZO-1 or ZONAB expression in RPE cells, we next assessed whether the changes in the RPE morphology lead to functional alterations by fluorescein angiography.
Lpcat3-deficient mouse models therefore provide an unprecedented opportunity to study the physiological and pathophysiological consequences of manipulation of membrane phospholipid composition in vivo.
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This indicates that changes in lifespan are likely the consequence of manipulations to corazonin neuronal populations and not solely caused by increased hybrid vigor or differences in genetic backgrounds.
Likewise, in Spodoptera littoralis caterpillars immune function declined, but the cost of nucleopolyhedrovirus increased, as a consequence of manipulations of dietary protein levels [ 57].
Expression of endogenous carotenoid genes is often altered as a consequence of manipulations modifying the levels of biosynthetic intermediates in the pathway.
Mitochondria in skeletal muscle tissue experience rapid and characteristic changes as a consequence of manipulations of muscle use and environmental conditions. 1 Decreased mitochondria content and functional capacity are common muscle pathophysiological traits implicated in the development of mitochondrial myopathy.
Temporarily disruption of pMTG functioning post-TMS directly led to performance deficits during tasks of high semantic control requirements, disproving the alternative view that brain activation in pMTG during fMRI is a by-product rather than a causal consequence of manipulations in executive semantic demands.
The MCS stands as a likely candidate to mediate the behavioral, hormonal and metabolic consequences of nutritional manipulation [24].
We studied the consequences of behavioural manipulation of the geometrid moth Thyrinteina leucocerae by its parasitoid wasp (Glyptapanteles sp., Braconidae) on parasitoid survival in the field in Brazil.
Clinical applications require further studies regarding safety, immunogenicity, and consequences of genetic manipulation [ 41].
mTOR-independent autophagy is perhaps a more interesting target for drug discovery, as targeting this pathway may avoid the pleiotropic consequences of mTOR manipulation in a disease context.
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CEO of Professional Science Editing for Scientists @ prosciediting.com