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Based on our observations, this host defense peptide could be considered in the future as a therapeutic option for dampening the pathologic consequences of inflammation and sepsis.
The functional significance of this change in insular microstructure was supported further by our between-subject analysis that demonstrated a correlation with individual susceptibility to inflammation-induced fatigue, one of the earliest and most commonly observed consequences of inflammation and a key symptom of depression (13,39).
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Protein malnutrition is both a cause and consequence of inflammation and related comorbidities for maintenance hemodialysis (MHD) patients.
However, radiographic changes indicate chronic changes and damage of the bone and are the consequence of inflammation and not active inflammation itself.
Elastin degradation has been investigated by several groups [ 14, 41- 45] conducting analyses of the cleavage pattern and of proteases involved as a consequence of inflammation and macrophage activity.
This shows that increased nNOS is not an obligate consequence of inflammation and hence strengthens the causative link between nNOS and muscle weakness in arthritis.
While these mutations are most likely a consequence of inflammation and not the cause of RA, they would be expected to affect disease progression [ 1].
Conversely, it may be that patients with RA have significantly modified their risk factors for the metabolic syndrome as a consequence of inflammation and that the addition of GC use cannot worsen these further.
Ulcers in the stomach and duodenum result when the consequences of inflammation allow stomach acid and the digestive enzyme pepsin to overwhelm the mechanisms that protect the stomach and duodenal mucous membranes.
While the consequences of inflammation on tumour initiation and progression are well studied [ 3, 4], the relationship between inflammation and viral infections in carcinogenesis is much less understood.
The clinical manifestations of RA are the consequences of synovial inflammation and the subsequent degradation and destruction of cartilage and bone.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com