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To determine the molecular consequences of incorporation of WT ESCs into the mdx musculature, we performed microarray analysis to search for restoration of markers dysregulated in the mdx muscle.
This behavior of Y766F could plausibly confer a small selective disadvantage, given the excess of rNTPs over dNTPs in vivo and the deleterious consequences of incorporation of rNTPs into DNA.
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The methicillin-resistant S. aureus (MRSA) strains are very often classified as multidrug resistant (MDR), which is a consequence of incorporation of many other determinants of resistance into the sequence of SCCmec, which acts as a hotspot of integration for genetic mobile elements such as plasmids, transposons, and insertion sequences (Lowy 2003; Stefani and Goglio 2010).
Dalgaard, J. Causes and consequences of ribonucleotide incorporation into nuclear DNA.
Moreover, the consequences of the incorporation of the RAMI studies in the IFMIF design are presented and the main outcomes of these analyses are shown.
In this study, we report the structural and functional consequences of the incorporation of the nonphysiological sialic acid, N-propanoyl neuraminic acid, into glycoconjugates of HL60-I cells.
To determine the molecular consequences of the incorporation of WT ESCs into the mdx fat, gene expression profiles were investigated.
The functional consequences of AZA incorporation into RNA include alterations in the processing of tRNA and rRNAs, leading to inhibition of protein synthesis [5], [17] [20].
We next compared the transcriptional competences of rH1-chromatin vs. chromatin to ascertain the functional consequences of H1 incorporation.
We then determined the consequences of covalent incorporation of an rNMP residue at the primer terminus on the rates of translocation, the rates of primer strand transfer between the polymerase and exonuclease sites, and the dNTP binding rates.
Among these, the orthologue of the Escherichia coli MutT (MTH1) hydrolyses oxidized purine nucleoside triphosphates, protecting mtDNA from the consequences of mis-incorporation during replication or repair.
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