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However most of the detected cis-eQTLs in these datasets were only detected in one of the two tissues, suggesting that more insight can be gained in the functional consequences of genetic variation by performing genetical genomics studies using different types of cells and tissues.
The extent, origins and consequences of genetic variation within human cell lines are studied, providing a framework for researchers to measure such variation in efforts to support maximally reproducible cancer research.
Functional consequences of genetic variation in primates on tyrosine hydroxylase (TH) expression in vitro.
Understanding the functional consequences of genetic variation, and how it affects complex human disease and quantitative traits, remains a critical challenge for biomedicine.
This study shows that PAXgene isolated peripheral blood RNA is a powerful resource for investigating functional consequences of genetic variation.
To fully understand the functional consequences of genetic variation, we have to integrate across these levels of information.
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This sporadic fluorescence might be triggered by unknown environmental factors or a consequence of genetic variation within the population.
The functional consequence of genetic variation in gene regulatory elements, for example, could be assessed using information from transcription factor binding site databases, and such information could be incorporated into future versions of Mouse SNP Miner.
As suggested by Stear et al. [ 50], the genetic variation in fecal egg counts in lambs is a consequence of genetic variation in worm length and hence worm fecundity; in contrast, mature sheep may be able to regulate both fecundity and worm number.
Here we aim to reveal the functional consequence of genetic variations in the SNCA genomic region.
In this study, we demonstrated the functional consequence of genetic variations in the SNCA genomic region and showed that the genetic association of some variants correlates with biological function, in particular regulation of SNCA expression levels.
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