(D ) If homing occurs in the late germline cells that contribute to sperm or eggs, the offspring will remain heterozygous in most tissues and avoid the consequences of drive-induced disruptions.
In this model, +/t males are less likely to successfully fertilize eggs in sperm competition with +/+ males due to reductions in sperm quantity (as a consequence of drive τ) and sperm quality (described by the sperm competitiveness parameter c).
In the present case, the duplication has a strong, negative effect on male fertility that is a direct consequence of drive (Angelard et al. 2008; Atlan et al. 2003; Atlan et al. 2004) and should cause many other perturbations via overexpression of the six duplicated genes or rIST and Hosim1-SR activity.
The idea is that sending repeat traffic offenders and drunk drivers to clean and transport dead bodies at hospital morgues (rather than do community service among the living) might drive home the consequences of driving wasted.
Meanwhile, the new CRISPR technique for gene editing is hugely promising, but there are ethical concerns raised by Chinese experiments on human embryos and by unintended consequences of "gene drive" programs.
Here, we investigated the consequences of experimentally driven Hec1 deregulation on mitosis and chromosome segregation in an inducible expression system from human cells in which the transgene is inserted at a single chromosomal site [36].
To analyse the behavioural consequences of expectations driven by rhythmic versus symbolic temporal cues under different task instructions, RTs from correct responses were submitted to a repeated-measures analysis of variance (ANOVA), testing the three factors of instruction (speed vs. colour) rhythmic cues (valid vs. neutral) and symbolic cues (valid vs. neutral).
This is a nice review that more addresses bone loss directly following TJR as opposed to the consequences of wear driven osteolysis that can initiate many years after surgery.
And just as much of American society accepts promiscuity as the unfortunate but inevitable consequence of sex drive, so India accepts the trafficking of 14-year-olds in the same way.
One undeniable consequence of this drive – whether led by Nigel Farage and Ukip or the greater Switzerland wing of the Tories – is that it is hastening the break-up of Britain/the UK.
Differences among individuals in the centromere region accumulate as a consequence of centromere drive, leading to reduced compatibility of homologous chromosomes in hybrids and ultimately to postzygotic isolation, thus triggering speciation (Henikoff et al. 2001).
