Sentence examples for consequences of amplification from inspiring English sources
Targeting Myc oncogenic activity will require an understanding of whether amplification promotes tumorigenesis and the consequences of amplification in tumors adapted to oncogenic Myc.
However, their study focussed on the effects of XIAP knockdown, while we have stressed the consequences of amplification in the cancer context, where we showed that autophagy is inhibited by embelin in cancer cells lines with XIAP amplification.
Further it was demonstrated that these MFH samples showed frequent co-amplification of either 1p32 or 6q23, which was not observed in the liposarcomas, suggesting that the lack of differentiation may be a consequence of amplification of target genes located in these regions, like the ASK1 (MAP3K5) gene in 6q23 [25], [25].
Curiously, starting nucleotide in these two sets is always A. Although this nucleotide may represent a preferred site of truncation, identity in starting position can also be a consequence of amplification events that followed truncation.
Alternate SNP positions can be expected in a haploid genome as a consequence of amplification artifact, sequencing errors, mis-mapped reads, or novel mutations occurring during in vitro culture.
A third approach which might be taken to validate the premise would be to carry out studies directed at evaluating APP expression levels in individual neurons to address the presumed pathological consequence of amplification of the APP gene in cortical neurons in AD.
Only the highly variable CMA+ banding pattern previously found in Citrus L. and close genera [ 67] is similar to the variability found in Tanacetum, probably as a consequence of amplification or reduction in satellite sequences known to be particularly GC-rich [ 68].
To determine consequences of gene amplification and to identify a possible target gene of the amplicon we performed real time RT-PCR.
study the consequences of centrosome amplification in an epithelium.
Here, we investigate the consequences of centrosome amplification in the Drosophila wing disc epithelium.
Here, we present an in vivo study of the consequences of centrosome amplification in the Drosophila wing disc.
