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Phenotypic consequences of this abrogation are the failures of apoptosis and wing expansion.
This rules out general effects related to siRNA transfection per se and demonstrates that the observed reduction of Mad2 levels in PICH siRNA-treated cells is not simply a consequence of SAC abrogation.
Taken together, these results suggested that phosphorylation of the C/EBPβ RD abolishes the interaction between the TAD of C/EBPβ and PRMT4/CARM1 and as a consequence leads to abrogation of methylation of R3 LAP*/C/EBPβ1.
3142, 87 L.Ed.2d 171 19855), that Congress had failed to provide a clear statement of abrogation of the Eleventh Amendment.
It is possible that either through abrogation of the effect of E7 or as a result of epigenetic or mutational silencing of host p16 (O'Regan et al, 2008), the HPV+ve/p16−ve tumours lack the molecular consequences of E7 expression and that one of the consequences of this is lower radiosensitivity compared with HPV+ve/p16+ve tumours.
This abrogation of orange halo formation on CAS agar plates is a consequence of the disruption of the msmeg_6554 gene.
Although the depletion of SET8 abrogates 53BP1 accumulation at DSBs 11 (Fig 1F and G), this might be an indirect consequence of a global reduction of pre-existing H4K20me upon SET8 depletion (Fig 1B) rather than due to the abrogation of SET8's activity on H4K20 or some other unknown substrate(s) specifically at DSBs.
The resulting physiological consequences could include complete abrogation of OTOP1 function, haploinsufficiency, elevated OTOP1 expression, or creation of a fusion protein with a dominant-negative effect or novel gain of function [ 46], any of which would contribute to our understanding of the role of OTOP1 in human development.
One interpretation of our data is that abrogation of the ability of Akt to phosphorylate the Tsc1/2 complex has no functional consequences whatsoever for the animal.
(via Consequence of Sound).
The potency of flavopiridol was enhanced by abrogation of p53.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com