Yet currently, our ability to predict the functional consequences of these aberrations remains poor.
The consequences of these aberrations, decreased β-agonist responsiveness and increased responsiveness to bronchospastic stimuli, are entirely consistent with the spectrum of clinical phenotypes observed in asthma.
These distinct roles will help to predict the downstream consequences of genomic aberrations.
Recent studies have suggested that aneuploidy in malignant tumours could be a consequence of centrosome aberrations.
Furthermore, the in silico data mining approach used here for evaluating transcriptional consequences of the detected aberration shows the power of utilization of previously published gene expression data providing a rapid and cost-effective tool for the discovery of new biomarkers.
If the loss is a consequence of epigenetic aberration, the acquired invasive phenotype could possibly be reversed with the use of epigenetic drugs [ 18].
The considered influences of aberrations on LIOB and their consequences for retinal safety during ophthalmic surgery show the requirement for aberration correction.
Altered gene function in AML is often a consequence of distinct cytogenetic aberrations [ 4], but also results from mutations in genes like CEBPA (CCAAT/enhancer-binding protein, alpha), FLT3 (fms-like tyrosine kinase receptor-3), or NPM1 (nucleophosmin 1) [ 3, 4].
Although the incidence of children born with chromosomal aberrations is lower than for aneuploidies, these types of aberrations have approximately 80% paternal contribution and result in severe health consequences (Chandley 1991; Crow 2001).
In this paper we hypothesized that the observed disturbances of alternative splicing in ccRCC may be a consequence of changes in expression of splicing factors, in particular, of aberrations of quantitative relations between them.
