The aberrant DNA methylation found in the CIMP phenotype may be a consequence of a dysfunction in the machinery involved in establishing and maintaining normal DNA methylation [15].
Then another important question comes: Is the amygdala defect presented reflects an essential role of Mecp2 in the LA or a secondary consequence of a dysfunction of neurons projecting to the LA? Indeed, when compared to the pre-symptomatic effects of Mecp2 deletion in the cortex [10], [12], the physiological defects observed in the amygdala are delayed for several months.
This is important, as the behavioural consequences of a 5-HT dysfunction in mother can reflect negatively on newborn developmental health.
The link between infertility and sexuality is complex and bi-directional: infertility can be considered either as a cause or a consequence of a sexual dysfunction.
Taken together, intracellular Aβ accumulation may be both a cause and a consequence of an endolysosomal autophagic dysfunction in AD (Figs. 1c, 4).
Contemporary cardiology not only offers treatment of the signs and symptoms but also addresses the causes and consequences of cardiac dysfunction in a multidirectional manner.
However, this is the only study to have explored the functional consequences of mitochondrial dysfunction in a replicating human tissue as studies in human subjects are limited due to the availability of human tissue samples and a lack of robust stem cell markers.
One of the metabolic consequences of mitochondrial dysfunction is an impairment of fatty acid oxidation, thus leading to lipid accumulation [ 19, 20].
As with humans, both genetic and non-genetic factors may explain this variability, since the animals do not have a pure genetic background (B6CBACa Aw-J/A-Pdcd8) and the phenotypic consequences of mitochondrial dysfunction depend on a number of unidentified factors.
My own view is that the police in this country do an impressive job and unjustly carry the consequences of a much wider social dysfunction.
