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The function of the horny layer as an impervious barrier may be seriously impaired, with two important consequences: loss of water from the skin leads to desiccation of the horny layer, which in turn leads to cracking, increased scaling, and soreness; and loss of the barrier function causes increased absorption of medications applied to the surface of the skin.
Similar to other disease states, the change in demographics of cardiovascular disease and the increased burden on women is attributed to the negative pathologic consequences (loss of antioxidant, anti-inflammatory, and neuroprotective properties) associated with the cessation of ovarian function [ 85, 86].
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In consequence, loss today is a supremely awkward category, bulging with everything from mittens to life savings to loved ones, forcing into relationship all kinds of wildly dissimilar experiences.
As a consequence, loss of peripheral tolerance ensues.
Polarization during cell growth by directed membrane trafficking is essential for cell division, therefore we hypothesized that GFP-AR149 expressing cells may exhibit retarded cell cycle progression and as a consequence loss of viability.
As a consequence, loss of DKK3 may promote hyperactivation of the PCP pathway, thereby potentially enhancing tumour aggressiveness.
As a consequence, loss of Giα proteins led to a defect in the activation of Akt and ERK1/2 by EGF and HB-EGF.
In consequence, loss of control due to a life-threatening illness might be interpreted by patients as "punishment", "weakness" or "irreparable loss" – illness has no positive meaning, no "signal" to change aspects of life.
Probably as a consequence, loss of ULBP1 drivers, and even ULBP1 itself, had little detectable effect on the capacity of HAP1 cells to stimulate a response (data not shown).
This second "anaphase" steady state is also missing in cells that express nondegradable cyclin B and S1121A separase, and as a consequence, loss of tension caused by APC/C activation causes the system to revert to a prometaphase-like state.
As a consequence, loss of the β-catenin-mediated differentiating effect promotes a dedifferentiated state of cells, which in terms of cancer represents a more malignant status than a well-differentiated one.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com