The authors could show that the peptide interacted with BCR/ABL endogenously expressed in leukemic cell lines and, as a consequence, led to a decrease in cell growth and induction of apoptotic death specifically in cells expressing the leukemia-associated fusion protein.
These two consequences lead to an enhancement in PL intensity for the MQW-NPA samples compared to the as-grown GeSi MQW sample.
Although tautomerism is a well-known and well-documented phenomenon, it has long been disregarded in the field of drug design, which, as a consequence, leads to a possible misinterpretation of ligand binding interactions.
It was shown that ATP release from lysed erythrocytes provides sufficient extracellular concentration of ATP (normally being quite low) to induce activation of a non-selective ion channel P2X7 in murine T cells and, as a consequence, leads to a cascade of events, including externalization of PS [66].
Coronary endothelial dysfunction in CHF may be due to decreased DDAH, which in consequence, leads to a higher ADMA level [ 40].
In general, adsorption energies for both molecular configurations significantly differ, which in further consequence leads to a nonequal distribution or even breakup of both enantiomers depending on the adsorption angle.
Incorrect teeth contact caused by, for example, tooth loss, bruxism, and nontreated dental caries are the source of stresses in temporomandibular joints, which sometimes can lead to activation of a cascade of unfavourable events, which as a consequence leads to a serious disorders.
Increasing monetary and financial instability and fear of hyperinflation with possibly dangerous social consequences led to the formation in 1925 of a national union government, intent on restoring the gold standard but at a more realistic parity level.
This result leads to a consequence for the nth power of an arbitrary network with k-hops.
