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There is a growing concern about the rapidly increasing incidence of obesity and its pathological consequences in the development of type 2 diabetes (T2DM) among human populations in the developed world [98].
Exposure to PM2.5 can enhance antigen-presenting cell phenotypes on circulating cells, which may have consequences in the development of allergic or autoimmune diseases.
In addition, it is unclear whether significantly altered gene expression changes are causes or consequences in the development of diabetic cardiomyopathy.
The mechanism of health effects from these two exposures might be similar and would have life-long consequences in the development of the respiratory system.
Disruption of just one of the two members of miR-1 family, miR-1-2 causes profound consequences in the development and maintenance of cardiac physiology.
This observation, that the manipulation of strings of symbols can produce new information, may have considerable consequences in the development of new avenues for systems biology, and will be at the heart of the present review.
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An unintended consequence in the development of Confucian thought in that context was the prominent rise of the metaphysically significant Confucian texts, notably Zhongyong ("Doctrine of the Mean") and Yizhuan ("The Great Commentary of the Classic of Changes"), which appealed to some Buddhist and Daoist thinkers.
As the behaviour of these networked systems can have important consequences, interest in the development of methods to control them to either achieve a goal state or avoid undesirable states is also increasing.
This polymorphism has important biological consequences, especially in the development of blood transfusion reactions, autoimmune neutropenias and the severity of renal disease in systemic vasculitis [ 6, 46].
Thus each of these proteins and microRNA could serve as important protein interaction/target hubs that if deregulated, will have important consequences in the normal development of a cell.
This would result in a lesion of the vascular endothelium and, in consequence, the development of cardiovascular disease.
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