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It should be noted, however, that the periodic perturbations induced by drug switching may result in highly complex behaviour, with unpredictable and frequently unfavourable consequences for outbreak control.
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Vaccination strategies were categorized by vaccine disease control strategy (preemptive use for endemic disease or to prevent an outbreak, and reactive use for outbreak control) and vaccine delivery strategy (community-based routine, community-based campaign and school-based).
The immunization strategy discussed in this paper is not the only option for outbreak control agencies.
Nonetheless, mumps outbreaks in well-vaccinated populations continue to occur, posing challenges for outbreak control.
Hence, for each disease, we assumed that the conditions for outbreak control are PIR1<1/R and PIR2<1/R.
Third-generation vaccines such as MVA may not be optimal for outbreak control.
The careful consideration of cholera vaccination for outbreak control in Haiti yielded valuable lessons.
When developing recommendations for outbreak control, criteria varied with the 18 countries (Tables 1 and 2).
In consequence, outbreak control is more difficult, but emergence of drug resistance is relatively uncommon.
Diagnosis is also important for surveillance, outbreak control, and research related to vaccine and drug development.
In practice the quality of surveillance and therefore the probability of disease detection can vary considerably, with consequences for disease control such as outbreak containment or discontinuation of control measures once freedom from disease has been achieved.
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