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The responses to these three stresses involve partially overlapping pathways [ 65- 67], as cold stress causes membrane leakage and, as a consequence, the activation of the physiological responses also observed in high salt and osmotic stresses [ 68].
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It is likely that the upregulation of these pathways in cells with functional PTPRJ are the consequence of the activation of tumour suppressor activities, such as controlling cell proliferation and proapoptotic signalling through dephosphorylation of VEGFR, MAPK and PI3K pathways [ 16– 16].
As a consequence of the activation of growth factor receptors, Ras is present in its active form on the inner plasma membrane.
Additionally, an important consequence of the activation of these signalling pathways upon excitatory neurotransmission is that they can regulate the activity of nuclear factors thereby triggering changes in gene transcription.
Although it has been reported that OIS is a consequence of the activation of DDR [19] [22] we observed that in astrocytes DDR activation does not necessary lead to senescence.
An important consequence of the activation of cells in the innate immune system is the production of pro-inflammatory cytokines, which help co-ordinate the immune response and promote inflammation at the site of infection.
One consequence of the activation of cycB/Cdk1at G2/M is the phosphorylation of Emi1.
The upregulation of the other members appears to be an indirect consequence of the activation of the β-catenin signalling.
Treatment with 3MC resulted in the anticipated induction of CYP1A1 as a consequence of the activation of the AhR.
A consequence of the activation of macrophages is the release of free radicals in an oxidative burst.
Puberty changes occur as a consequence of the activation of the hypothalamic pituitary gonadal axis (Buck Louis et al. 2008).
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