One consequence, on the level of epistemology, is a direct denial of the conception of 'logic' as the rule-book of individual, introspectively experienced persuasion (a conclusion in line with rhetoric's understanding of reasoning as crowd persuasion).
Since inhibition of p38 MAPK could effectively block the morphine-induced apoptosis in wild type microglial cells (Fig. 4), its consequence on the level of phosphorylation of p38 MAPK was next determined in wild type and TLR9 deficient microglial cells with 10 µM morphine treatment for 24 hr.
In consequence, on the level of mature granulocytes, both models agree with each other and the clinical data as well, because the differences in efflux from the stem cell compartment are sufficiently small to be compensated by the feedback controlled amplification in subsequent bone marrow compartments.
Two third of the children and almost all parents did not think that refusal to participate could bring negative consequences on the level of health care or personal dependence on the physicians.
Disrupting critical circadian clock genes not only disrupts rhythmicity of target gene expression, but it can also have dramatic consequences on the level of expression of many target genes [ 73. 76- 77].
We have not conclusively proven the functional role of any polymorphism in regulating the expression of CEGs through in vitro or in vivo experimental validation, and many of the SNPs in the vicinity of the CEGs could be neutral (i.e. have no consequence on the expression levels).
Consistently, deletion of the binding site and the use of specific miR-17 inhibitor did not have any consequence on the APEX1 level.
The consequence on the normative level, however, is that they become immune against any kind of critique from other people or institutions.
"All of this sounds like bad science fiction," Dr. Layne said, "but if it does get going in people, it will have major consequences on the medical level, the scientific level, the economic level and the societal level".
