Sentence examples for consequence on the expression from inspiring English sources

We have not conclusively proven the functional role of any polymorphism in regulating the expression of CEGs through in vitro or in vivo experimental validation, and many of the SNPs in the vicinity of the CEGs could be neutral (i.e. have no consequence on the expression levels).

We demonstrated an association between one GHSR promoter SNP and weight loss during a 3-year follow-up and consequently showed that this SNP might have functional consequences on the expression of the GHSR gene.

We specifically tested Sox2 and indeed overexpression has negative consequences on the expression of markers of terminal differentiation, Filaggrin and KRT10.

Decreased levels of minor snRNPs such as U11 may further enhance this situation and have deleterious consequences on the expression of mRNAs containing U12-type introns in cells of SMA patients.

This has consequences on the expression of Fas and Dlx5.

In another study lack of Pkh1 or Pkh3 had not relevant consequences on the expression profiles [ 17].

During cell wall assembly, biosynthesis of phenylpropanoid, protein, and carbohydrate constituents appeared to be inter-dependent, and the deficiency in a key-enzyme of the lignin pathway had consequences on the expression of several genes involved in cell wall metabolism.

In summary, muscle analysis of various LGMD patients and of related animal models shows that the absence of or defects in β- and δ-sarcoglycan has dramatic consequences on the expression of all other subunits, whereas defects in γ-sarcoglycan have the least effect on expression of the other sarcoglycans.

Sex chromosome imprinting could directly modify expression of testis-specific genes by changing the amount of available chromatin-associated proteins such as HP1, but it is also possible that imprinting effects on master transcriptional regulators in the male germline could have downstream consequences on the expression of testis-specific genes.

Since there is ample evidence for the physiological relevance of CREM mediated gene regulation, these changes in the expression of functionally distinct CREM spliced variants are likely to have biological consequences on the expression of down-stream target genes involve in uterine activity during gestation and parturition.

Some of the earliest studies of post-transcriptional regulation, which concerned bacterial operons involved in amino acid biosynthesis, established that some leaders encoded a short peptide (known as the leader peptide) whose translation had regulatory consequences on the expression of downstream genes [ 6– 10].