Sentence examples for consequence on gene expression from inspiring English sources
SNPs belonging to ROBO1 and LPHN2 were also located within intronic sequences, but were not predicted to have a functional consequence on gene expression and/or function.
Integration of MLV-derived retroviral vectors may have significant consequences on gene expression and homeostasis of transduced and transplanted target cells, particularly in the hematopoietic system.
Using different model systems the functional consequences on gene expression of EWS-FLI1 have recently been studied in whole genome gene expression profiling analyses, and the target gene sets were compared to deregulated genes in ESFT to test for biological relevance (see [4] for a review).
This up-regulation has different consequences on gene expression.
Defects in the regulation of this phenomenon can have important consequences on gene expression).
To characterise these anomalies and define their consequences on gene expression, we undertook a study combining array-CGH analysis and expression profiling using specialised arrays.
Using the same cell line we had previously demonstrated a modest gain of DNA methylation (at 100 days in culture) with severe consequences on gene expression [ 8].
To date, no study has investigated the broader consequences on gene expression of siRNA-mediated knockdown of EPHB4 in prostate cancer.
Recent advances in next generation sequencing and accurate repeat genotyping algorithms enabled us to investigate repeat variation in tumor genomes more comprehensively, and to study their potential consequences on gene expression.
Further studies geared to understanding the mechanistic origins of these aHCF as well as their consequences on gene expression and function will be required to fully elucidate their role in cancer initiation and progression.
By now there is increasing evidence that low BPA concentrations adversely affect the epigenome of mammalian female germ cells, with functional consequences on gene expression, and oocyte development and quality.
