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"We are a new elite and that is an inevitable consequence of transformation," he says.
As a consequence of transformation, the ratio between d- and l-isomers was changed due to the increment of l-lactate and the decrement of d-lactate, but no significant differences were found in total lactate concentration between the host and transformant cells.
However, it is not known whether the alterations of MVA pathway contribute to cancer etiology or whether its dysregulation occurs as a consequence of transformation.
It is not yet clear whether Yap dysregulation is a feature of the hyperproliferative states that precede HCC or is a late consequence of transformation.
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The clones had replaced 1 3% of their chromosomes with donor DNA at independent locations, underlining the genetic consequences of transformation for single competent cells.
Thus, transcripts exhibiting highly significant over expression in all classes of abnormal astrocytes, including trisomic BG01V APCs, CCF-STTG1 astrocytoma cells and glioblastoma patient samples with respect to diploid H9 APCs (Table 1, GND > C) may be diagnostic markers of transformation and/or potential therapeutic targets (i.e. changes in gene expression that are consequences of transformation).
Therefore, this study shows that most epigenetic modifications occur as primordial and essential events during the establishment of malignant transformation in this murine melanoma model, rather than as a consequence of cell transformation [ 27].
While the roles of viral gene products in the transformation process have been described in detail, whether genetic alterations are introduced as a consequence of EBV transformation is less well understood.
It has been suggested that the different molecular subtypes of breast cancer arise from the transformation of different stem or progenitor cell populations which retain, or acquire as a consequence of the transformation process some or all of functional characteristics of normal stem cells [ 14].
This sale is a long-overdue consequence of the transformation of Airbus from a consortium to a stand-alone company.
For better or worse, it's an unintended consequence of a transformation that began with the '82 vintage.
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