These differences may be a consequence of the site-specific differences in osteoclast activities [21] [23], however the observations also imply that the mechanisms regulating site-specific osteoblast behaviour/matrix production are autonomous.
It should be noted that there is another important consequence of locating the site of action of IP on the OMM.
The difference is possibly a consequence both of the site of infection and the type and extent of immune response that is elicited.
It has been shown, however, that the faster viral decay with raltegravir could be a consequence of the particular site of action of InIs within the viral life cycle and may not be due to an overall increased removal rate of replication-competent viral compartments by raltegravir [23], [49].
Finally, we cannot exclude that some of the clone-specific alterations might be a non-specific consequence of the integration site of reprogramming virus rather than a consequence of CDKL5 absence.
It is plausible that the advantages in the ultrasound group with respect to proper guidewire insertion can not only be seen as a consequence of ultrasound usage as well as but also as a consequence of the insertion site.
The reason for this is not clear but it may be a consequence of the integration site of the transgene and the lack of sequences from within the body of the BLG gene and/or in its 3'-terminal end, which confer integration site independence [ 40].
A large number of equivalent ligand atoms in equivalent positions in space (as a consequence of the binding-site superposition produced by IsoCleft) may point to binding-site atoms in the query protein that are important from a molecular recognition point of view.
