Sentence examples for consequence of the mutations from inspiring English sources
Unlike Ebola, flu or polio, cancer is a disease that arises from within — a consequence of the mutations that inevitably occur when one of our 50 trillion cells divides and copies its DNA.
A possible consequence of the mutations is cleavability by monocytic/macrophage-specific proteases.
However, whether the site-specific occurrence of GNAQ mutations is a consequence of the mutations themselves or represents different target cell populations needs to be further determined.
The in vivo consequence of the mutations that produce a PTC-containing transcript is, however, hard to predict from these analyses.
The diminished SUN2 transcript levels in senescent patient cells might be a consequence of the mutations in SUN1 and SUN2, respectively, leading to a weakening of the interactions of the LINC complex or through perturbed mechanotransduction and subsequent aberrant signalling pathways which in turn can affect the levels of cellular and extracellular components.
This mutational genetic variance both depends on the mutation rate and on the phenotypic consequences of the mutations (the mutational effects).
At the variant level, alterations were delineated for the type (nature) of the mutation, location of the mutation in the protein, reported functional consequence of the mutation in the literature, and reported incidence of the mutation in a subset of cancers.
The docking conformations of original and mutant kinases are visualized using JSmol (http://wiki.jmol.org/index.php/JSmol) to highlight the structural consequence of the mutation (Fig. 2b).
The main consequence of the mutation is a change in the relative orientation of the two globular calcium-binding domains, causing the hydrophobic patches in these domains to be closer and much less accessible to interact with the target enzymes.
Although this bone phenotype could be a direct consequence of the mutation, other alterations (cardiovascular, neuromuscular, fat and hematopoiesis) may also be involved and deserve further exploration.
