Sentence examples for consequence of the mutation from inspiring English sources

What caused the piebald patterning was a different consequence of the mutation: the cells did not multiply as well as they moved through the skin, leaving the animals' underbellies and extremities often devoid of the pigment needed to make dark fur.

At the variant level, alterations were delineated for the type (nature) of the mutation, location of the mutation in the protein, reported functional consequence of the mutation in the literature, and reported incidence of the mutation in a subset of cancers.

The docking conformations of original and mutant kinases are visualized using JSmol (http://wiki.jmol.org/index.php/JSmol) to highlight the structural consequence of the mutation (Fig. 2b).

The main consequence of the mutation is a change in the relative orientation of the two globular calcium-binding domains, causing the hydrophobic patches in these domains to be closer and much less accessible to interact with the target enzymes.

Although this bone phenotype could be a direct consequence of the mutation, other alterations (cardiovascular, neuromuscular, fat and hematopoiesis) may also be involved and deserve further exploration.

While WT Akt overexpression led to increased phospho-Akt levels (Ser473), this effect was not detected with the mutant isoform, possibly due to conformational changes in the antibody-binding site as a consequence of the mutation itself (Figure 3A).

Unlike Ebola, flu or polio, cancer is a disease that arises from within — a consequence of the mutations that inevitably occur when one of our 50 trillion cells divides and copies its DNA.

It is important to understand that the emergence of a quasispecies is not something that has been put into the model ad hoc, but is a necessary consequence of the mutation-selection equations.

A possible consequence of the mutations is cleavability by monocytic/macrophage-specific proteases.

However, whether the site-specific occurrence of GNAQ mutations is a consequence of the mutations themselves or represents different target cell populations needs to be further determined.

This mutational genetic variance both depends on the mutation rate and on the phenotypic consequences of the mutations (the mutational effects).