Sentence examples for consequence of the mutant from inspiring English sources

Serum selenium was reduced in these animals, which was a direct consequence of the mutant TRα1 and not related to their metabolic alterations.

Only one transgenic line, 13a, exhibited nondisjunction levels significantly different than the wild-type transgene, and this is likely a consequence of the mutant protein being expressed at lower levels than wild type (Table 1, Figure S2).

While it is unknown if these pathways are altered as a direct consequence of the mutant SOD1 protein's toxic gain of function or as a secondary defence, the data contribute further evidence of the potential for PI3K and AKT activators and PTEN inhibitors as therapeutic agents to slow the progression of motor neuron degeneration.

As a consequence, replication of the mutant viruses in MDCK cell culture is strictly dependent on exogenously added proteases targeting monobasic cleavage sites, such as trypsin.

As the transferrin receptor is located correctly at the plasma membrane in TS-mutant cells at 42°C, impaired endocytosis is a direct consequence of the temperature-sensitive effect of the mutant clathrin.

However, it was proposed that the observed defects could be an indirect consequence of the particular mutant strains used [21].

This 2k32 mutant was confirmed to be a consequence of the cal1 mutation, as the mutant phenotype is complemented by a cal1 transgene (Y. Unhavaithaya and T. L. Orr-Weaver, unpublished data).

However, several alterations in gene expression and regenerative potential of skeletal muscles have also been reported as a consequence of the expression of mutant SOD1 in muscle.

Indeed, recent studies suggest that the muscle hypotonia found in iDEND patients is also a consequence of the presence of mutant KATP channels in neuronal tissue [ 16].

As a consequence of the folding defect, mutant SERPINA1 molecules polymerize and aggregate in the endoplasmic reticulum (ER) of hepatocytes, forming large intrahepatocytic globules that are the pathological hallmark of the disease.

Although we have no in vitro data on the functional consequences of the W210R mutant, in silico analysis suggests that the amino acid change is severely damaging.