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Such local shift changes are a mandatory consequence of the modification of the peptide sequence, in this case with the N-terminal methionine, and reflect local changes in the electronic environment.
Because it is currently not possible to directly measure mono-ADP-ribosylation in cells by using tools like antibodies, we decided to focus on a kinase so that kinase activity can be determined in response to mono-ADP-ribosylation as an indirect mean to investigate the consequence of the modification.
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Exposure to moderate hypoxia may lead to neurological phenomena such as paraesthesia, numbness or pain, possibly as a consequence of the modifications that appear in small DRG neurones.
As a consequence of the modifications, the R 2 values between the experimental and calculated solvation free energies increased from 0.68 and 0.67 to 0.88 and 0.85 for training and test sets, respectively.
We attribute alterations in these forces as a combined consequence of the modifications in stress under the simultaneous action of rotation and electrical forcing and its interplay with the elastic stress originating from the viscoelastic effects.
Thus, the enhanced LTP previously observed in DAP12KI hippocampus may be the consequence of the modifications of NMDARs.
In this way, the mechanism adapts to the tracking performance: the curvature profile remains invariant whereas the speed profile may exhibit new peaks as a consequence of the modifications of the control patterns.
We and others have demonstrated the presence and structural and functional consequences of the modification by 3-nitrotyrosine on plasma as well as tissue proteins [ 16].
The occurrence and frequency of S-alleles in this region could be compared to those of other regions in order to support previous theories on the origin of North African apricots, as well as to examine the genetic consequences of the modification in the sexual reproduction strategy of fruit trees.
However, the full biological significance of this information will only be realized through the identification of the enzymes that regulate each specific phosphorylation site, the conditions under which the phosphorylation occurs, and the functional consequences of the modification for protein function (12).
Moreover it will be important to define to what extent the consequence of this modification overlaps with the inhibitory effect of Ser-9 phosphorylation as well as other regulatory mechanisms that target GSK3β [ 43- 45].
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