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It seems that the latter beats the former; suffice it to say that the Mendel laws are trivial consequence of the DNA replication mechanisms.
In this study, we profiled proteins and genes whose expression is changed in immature maize embryos as a consequence of the DNA damage produced by CPT.
Also, aggresome formation did not occur as an immediate response to the DNA injury but appeared to be a delayed consequence of the DNA damage.
Damage of the type seen with the φC31 integrase, has not been detected with the tyrosine recombinases, is likely to be a consequence of the DNA cleavage and strand exchange mechanism of the serine recombinases (reviewed in [ 16]).
Nevertheless, it is possible that modifications of the chromatin structure as a consequence of the DNA methylation block the binding of a protein factor in vivo although the factor is methylation insensitive in vitro, as is known for NF-Y (Ammerpohl et al, 1997, 1998).
It appears that the higher p53 protein levels are the consequence of the DNA damage response following CDV treatment that affects the expression of regulators of p53 (such as MDM2, MDM4, and CDKN1A) resulting in a rapid stabilization of p53 via blocking of its degradation.
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The genome of a cancer cell carries somatic mutations that are the cumulative consequences of the DNA damage and repair processes operative during the cellular lineage between the fertilized egg and the cancer cell.
Doubling the amplicon length, an exponential loss of PCR efficiency was observed in maltonis and malten treated DNA, while cisplatin (CDDP) treatment induced, as expected, a linear decrease of DNA amplificability as consequence of the induced DNA modification.
A significant consequence of the intimate DNA wrapping around the histone core is that it sterically occludes other DNA-binding proteins.
As a consequence of the increased DNA binding by HEB MyoD complex, the activity of the myogenin promoter was increased by six-folds.
It is unknown whether this reflects a consequence of the associated DNA repair defect or a result of a progressive functional decline.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com