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To investigate the possibility of function blocking antibodies to NRP1 as potential therapeutics, and study the consequence of targeting NRP1 in murine tumor models, panels of antibodies that cross-react with human and murine NRP1 were generated from a designed antibody phage library.
Inhibition of nucleic acid synthesis can also occur as a consequence of targeting other metabolic pathways.
This study demonstrated the direct functional consequence of targeting NF- κB in NPC.
The consequence of targeting tumour cells with ALM is effective inhibition of tumour cell growth in vitro.
Exposure to estrogenic EEDs in utero was associated with adverse health effects, with the potentially unanticipated consequence of targeting developing heart valves.
This dual consequence of targeting CDK11 adds unique functionality not observed by targeting family members such as CDK1, CDK2, CDK4, or CDK6.
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In view of the disagreements about the political consequences of targeting or universality generally, it is useful to examine the evidence on preschool programs in particular.
The objectives of this analysis were to assess health and economic consequences of targeting hemoglobin (Hb) levels around 10-11 g/dL relative to 9-10 g/dL using an economic model and to explore the impact of different assumptions on cost-effectiveness.
Moreover, we analyzed the consequences of targeting a copper binding non-mitochondrial protein (PaMT1) to the mitochondrial matrix on the type of respiration and on lifespan.
In order to investigate the means and consequences of targeting GAATTC repeats for interruption, we chose to use a (GAATTC 108 allele already containing several point interruptions (Figure 1).
However, the consequences of targeting α6β4 integrin with an antibody on normal tissue homeostasis and repair processes haven't been yet studied.
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