Sentence examples for consequence of target from inspiring English sources

· Evidence of downstream pharmacodynamic effects as a consequence of target engagement.

As a consequence of target inhibition, a marked proportional decrease of monocytes has also been previously reported by other investigators [ 4].

To investigate the possibility of function blocking antibodies to NRP1 as potential therapeutics, and study the consequence of targeting NRP1 in murine tumor models, panels of antibodies that cross-react with human and murine NRP1 were generated from a designed antibody phage library.

Inhibition of nucleic acid synthesis can also occur as a consequence of targeting other metabolic pathways.

This study demonstrated the direct functional consequence of targeting NF- κB in NPC.

The consequence of targeting tumour cells with ALM is effective inhibition of tumour cell growth in vitro.

This dual consequence of targeting CDK11 adds unique functionality not observed by targeting family members such as CDK1, CDK2, CDK4, or CDK6.

Exposure to estrogenic EEDs in utero was associated with adverse health effects, with the potentially unanticipated consequence of targeting developing heart valves.

Another advantage is increased levels of phylogenetic information in target regions, compared to those targeted in UCE studies (A.R. Lemmon, unpub. data), as a consequence of targeting more variable regions of the genome.

However, mTORC1 inhibition per se can reduce the mRNA expression of mitochondrial genes and compromise the function of mitochondria in cultured muscle cells, implying that defects in bioenergetics might be an unavoidable consequence of targeting mTORC1 in vivo.

This is an inevitable consequence of targeting the TRα1 locus, as it eliminates the alternative splicing variant TRα2 and therefore results in a mildly increased production of the TRα1 GFP, about 2.5-fold [ 16].