Sentence examples for consequence of such mutations from inspiring English sources
Since Beclin 1 is a well-known tumor suppressor [2], [16], we therefore wanted to test the cell biological consequence of such mutations in the context of FYVE-CENT interaction.
To identify the functional state of the channel that this structure represents, we engineered phenylalanines at various pore-facing positions of the muscle acetylcholine (ACh) receptor (one position at a time), including the position that aligns with the native phenylalanine 246 of ELIC, and assessed the consequences of such mutations using electrophysiological and toxin-binding assays.
Since the bacterial complex I does not display the A/D transition this may be misleading for the study of the overall functional consequences of such mutations, not at the level of the enzyme as such, but for global consequences on the respiratory chain.
The consequences of expression of such mutations may be explored further by introducing such human hyperekplexia antimorphs as transgenes into mice.
We know that carcinogens, including toxic exposures such as radiation and chemicals, increase the frequency of such mutations.
Single amino acid changes are the main type of mutation causing this disease, and considerable effort has been dedicated to the understanding of the molecular consequences of such missense mutations.
As a common molecular consequence, such mutations are known to cause loss of PARKIN function, leading to impaired mitochondrial integrity [ 7].
The B. mallei indels observed upon passage could be the consequence of such a stress-induced enhanced mutation rate upon host immune response stress or upon that stress leading to reduced growth rate upon entering stationary phase in culture.
The consequence of such a patchwork of splice variants is that most mutations in the PCNT gene will not have global but tissue and even cell specific effects.
