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Co-expression of a pathway is likely to be a consequence of pathway regulation, for example by transcription factors.
We conclude that the extended system obtained as a consequence of pathway lengthening becomes more stable only when the added species degrades slower than it is being produced.
This analysis revealed that the classification was indeed a consequence of pathway activity and not a recapture of well-known clinical features, demographic features or disease history.
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Ingenuity Pathway Analysis results support several possibilities for ZAP70/Syk activation as a consequence of pathways activated by AF (Supplementary Figure S4).
For this reason, inhibition of IKK signaling is widely considered as a promising strategy for treating many illnesses; the challenge however is to fully recognize, and develop means to offset, the potential harmful consequences of pathway inactivation (Baldwin, Jr., 2001; Li et al., 2002; Bacher and Schmitz, 2004; Courtois and Gilmore, 2006; Karin, 2006).
An interesting consequence of independent pathway competition is that fairly small changes in kinetics of either pathway can cause large changes in average cell fate.
This may reflect interactions between these pathways, an interplay between the WNT and cadherin pathways is known to exist [49], or may be a consequence of poor pathway annotation.
The interviews were based on a semi-structured interview guideline covering the attitude towards the developed pathway and medical innovations such as treatment pathways and guidelines in general, key factors that influenced the implementation of the CHD pathway in a negative or positive way, and suggestions of improvement and behaviour changes in consequence of the pathway.
What is the consequence of Notch pathway activation in various cell types?
Elevated expression of AKT has been noted in a significant percentage of primary human breast cancers, mainly as a consequence of PTEN/PI3K pathway deregulation.
To demonstrate that the growth arrest effects seen for the constitutively active Ste2 - Fz 1/2 receptor chimeras are a consequence of mating pathway activation we have used a genetic approach: Deletion of the cyclin-dependent kinase inhibitor FAR1 partially reversed the growth arrest phenotypes.
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