Sentence examples for consequence of mutations from inspiring English sources

This implicates that the rigidity of the enzyme has been changed as the consequence of mutations.

Ras proteins are constitutively activated in 30% of human tumors, including lung cancer tumors, as a consequence of mutations in ras genes.

Deregulations of kinases as a consequence of mutations as well as over- or underexpression can cause abnormal changes in cellular signaling and, as a consequence, have implications for the progression of diseases such as cancer, diabetes and inflammation [1].

The heterogeneous nature of prostate cancer may be a consequence of mutations in different cell types (basal stem, transit amplifying or luminal cells) resulting in different malignant maturation pathways.

Although aberrant splicing has been shown to be a consequence of mutations or the abnormal expression of splicing factors (trans-effect changes) or mutations in the splicing sequences (cis-effect mutations), the connections between aberrant splicing and cancer initiation or progression are still not well understood.

However, the dysregulation of TFE3 or TFEB as a consequence of mutations in other tumor suppressor genes has not been reported.

They are defined by a number of criteria, including the sensitivity of this region of the viral fusion protein to loss of function as a consequence of mutation.

Population linkage disequilibrium occurs as a consequence of mutation, selection, genetic drift, and population substructure produced by admixture of genetically distinct ethnic populations.

KREPA3 function was further explored by examining the consequence of mutation of its N- and C- terminal ZFs (ZF1 and ZF2, respectively).

Loss of function of p53 as a consequence of mutation has been shown in 50% of human cancers [ 3].

Mutation is the source of variation on which oncogenic selection acts, and genomic instability is a consequence of mutation as well as a cause.