One might interpret the manifestation of expressive suppression in the dmPFC as a consequence of the internalization of societal norms, manners and mores that govern the acceptable and unacceptable times for emotional expression [29], [30].
Hence, the loss of cholesterol in the older cells would probably affect AMPAR displacement by lateral diffusion, similar to, and possibly as a consequence of reduced internalization (see Figs 3 and 4).
Both studies demonstrated that the relative increase in D2 receptor levels at the cell surface was not a consequence of impaired internalization but of decreased trafficking from endosomes to lysosomes and, as a secondary effect, enhanced recycling of the receptor to the plasma membrane (Ji et al., 2009; Marley and von Zastrow, 2010).
The expression of fully functional eGFP NPRA permitted detailed analyses of the consequences of receptor internalization and trafficking in HEK-293 cells.
A direct consequence of β1-integrin internalization is the disruption of integrin and F-actin-associated FCs, structurally organized by Talin and Vinculin.
It is unclear whether the vesicular compartmentalization of HER2 is a consequence of enhanced receptor internalization or an inhibition of receptor recycling, but recent evidence points to the latter.
As such, we focused on β1-integrin and F-actin-associated structural focal components (Talin/Vinculin) and postsynaptic proteins known to function in concert with F-actin and synaptic remodeling, because the direct consequence of β1-integrin internalization is the disruption of the structural components of FCs (Talin and Vinculin), which anchor the cytoplasmic tail of β1-integrin to F-actin.
Since the mode of internalization has a direct consequence on the subcellular localization and stability of the nanoparticle, it is imperative to consider these factors in live cell studies.
Responses developed irreversibly and were slower than for downstream Y1 receptor YFP internalization, a consequence of delayed maturation and stability of complemented YFP.
To clarify whether the NFAP internalization was the consequence of an endocytic mechanism, the indirect immunofluorescence staining was repeated in the presence of 5 µg/mL latrunculin B (latB).
