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Given this dual role of chaperones, diseases caused by the misfolding and aberrant trafficking of ion channels (referred to here as ion-channel-misfolding diseases) can be regarded as a consequence of insufficiency of the pro-folding chaperone activity and/or overefficiency of the chaperone ERAD role.
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It is tempting to speculate that the astrocytic swelling phenotype observed with male M5R−/− mice is a consequence of cerebrovascular insufficiency.
The metabolic derangements characteristic of diabetes in general is primarily a consequence of relative insufficiency of insulin secretion and/or insulin action [ 3].
In most cases, the affected children die within the first 6 months of life as a consequence of vascular insufficiency causing end-organ damage.
Activation of the p53 pathway following inhibition of Pol I transcription in tumour cells is not a consequence of ribosome insufficiency, suggesting that the cells are responding directly to perturbations in rDNA transcription [ 174].
These results argue that some tumors are a consequence of haplo-insufficiency or trans-dominant effects of the mutant allele.
While it is often said that the nutritional consequences of insulin insufficiency are of greater concern than the metabolic effects of hyperglycemia in CF, high blood glucose levels may also play an important role in pulmonary function decline, even in patients with only intermittent postprandial glucose elevation.
Inter-assay and laboratory disagreement could contribute to uncertainty when comparing results from studies investigating the prevalence or clinical consequence of vitamin D insufficiency.
On the other hand, T2DM develops as a consequence of relative insulin insufficiency and is characterized by hyperinsulinemia and insulin resistance for compensation.
Brain injury, as a consequence of cardio-respiratory insufficiency, is the most common cause of morbidity in premature and term infants.
The metabolic consequences of insufficient sleep may be the result of a lack of total sleep or insufficiency of a certain sleep component.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com