Sentence examples for consequence of genetic variants from inspiring English sources
Elucidating the functional consequence of genetic variants associated with disease provides essential insights into the molecular mechanisms that define human traits.
According to the thrifty genotype hypothesis, the high prevalence of type 2 diabetes and obesity is a consequence of genetic variants that have undergone positive selection during historical periods of erratic food supply.
A new study combining statistical fine-mapping with cell-type-specific functional annotations advances the understanding of the regulatory consequences of genetic variants associated with variations in blood-cell traits.
Future work needs to link characterization of gene families like our study with understanding of the functional consequences of genetic variants for bdelloids in natural environments.
The most responsive indicator, allelic diversity, is notable because it directly represents extinction of genetic variants, with direct consequences for alleles with present or future functional/adaptive importance.
For example, ClinVar intends to provide a catalog of genetic variants together with their clinical consequences, with over 120,000 variants at the time of writing [ 6].
It would also be impossible to describe the potential consequences of genomic analyses, because the implications of the majority of genetic variants found to date are not known.
As a consequence, large samples are needed in order to have sufficient power for the detection of genetic variants implicated in ADHD [ 18, 19].
Method And System For Functional Evolutionary Assessment Of Genetic Variants.
