As a consequence of genetic and epigenetic alterations, a cancer antigenome27 is generated, leading to the expansion of tumour antigen-specific T cells.
Elucidating the functional consequence of genetic variants associated with disease provides essential insights into the molecular mechanisms that define human traits.
Still, identifying causal variants and emergent vulnerabilities that arise as a consequence of genetic alterations remain major challenges.
More important, natural selection and other processes change gene frequencies in ways not governed by pure chance, so that no allele has an opportunity to become fixed as a consequence of genetic drift alone.
The argument of violating the independence of the farmer depends on the present economic situation (e.g. power of multinationals) and does not seem to be a consequence of genetic engineering as such.
Cancer, as well as other human disorders, has long been considered to result from the consequence of genetic mutations in key regulatory genes that reside in pathways controlling proliferation, cellular differentiation, DNA damage and repair.
Genetic mutations happen all the time, of course, whether as a consequence of genetic engineering or for no discernible reason whatsoever.
The team hopes to unpick whether the shifts they see are a result of fish moulding themselves to a new environment - a so-called plastic response - or are a consequence of genetic changes.
The chromosome-dependent variation might be a consequence of genetic or epigenetic differences among the sequences of subtelomeres; these differences might affect the balance between telomere shortening and telomere elongation.
When a chimpanzee teacher begins teaching his small-town students that they are living on a "planet where apes evolved from men," as a consequence of genetic experiments by human scientists, he sets off a ideological firestorm.
Here we aim to reveal the functional consequence of genetic variations in the SNCA genomic region.
