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This is an important finding indicating that the function and consequence of dysfunction cannot automatically be extrapolated from an apparent orthologue.
It is presently unknown whether the intracellular protein aggregation observed in most late-onset neurodegenerative diseases is a cause or consequence of dysfunction in these pathways [ 97].
Psychiatric symptoms are most likely a consequence of dysfunction of multiple cortical areas and sub-cortical brain structures in patients with schizophrenia.
This could be at least partly explained by the alteration of sound localization and distortion leading to impaired speech intelligibility as a consequence of dysfunction of inner ear and cochlear nerve by tumor and its treatment [ 35, 36].
The reduction in nocturnal melatonin levels with the abolition of diurnal melatonin rhythmicity may be the consequence of dysfunction of noradrenergic regulation and depletion of the melatonin precursor 5-HT by increased MAO-A activity, as already seen in the earliest preclinical AD stages [ 242].
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Toxicity manifest as noncancer endpoints essentially consists of the consequences of dysfunction of the whole physiological system, not of failures of any particular cell or gene.
Every year, there are over 350,000 people worldwide who are diagnosed with the tragically debilitating consequences of dysfunction in lower limb motor control, so it is obvious for the significance in searching for effective means of helping these people to regain ability to stand up and walk.
Heart failure was thus seen to be a consequence of systolic dysfunction and not diastolic dysfunction.
This usually occurs as a consequence either of dysfunction of the prefrontal cortex, or of diseases of the basal ganglia which disrupt the associative pathways to the prefrontal cortex.
Behavioral consequences of dysfunctions of neurological origin or of aging on walking abilities can be reliably assessed by analyzing footprint patterns [6], [9], [13].
This finding suggests that loss of orgasmic function may not only occur as a consequence of erectile dysfunction as described by others (22) but also may actually precede erectile dysfunction, at least as perceived by some men with diabetes.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com