This padlock model is developed further to suggest two distinct consequences of domain motion: in the UvrA2B DNA complex, domain motions lead to translocation along the DNA, whereas in the tight UvrB DNA pre-incision complex, they lead to distortion of the 3′ incision site.
A consequence of such domain or area specificity is that the information assembled about self-regulation is published in separate journals.
As a consequence of the domain movement, the distance of this salt bridge is reduced from 4.3 Å (NADH complex) to 3.8 Å (L-arginine and agmatine complex), which of course will strengthen this interaction.
We developed a categorization system, which allocates membership of TFs to families as a consequence of their domain architecture.
The greater susceptibility of apoE4 to proteolytic cleavage, and the subsequent prolongation of Aß interactions, is thought to be a consequence of differential domain interaction.
The same may also be true for the LIM class; alternatively the apparent polyphyly of LIM-class homeodomains could be a consequence of LIM domain loss or artefactual placement of some ZF-class homeodomains in phylogenetic analyses.
Structural analysis of the enzyme revealed an unexpected dimer formation as a consequence of a domain-swapping event involving its N-terminal region.
The results related to the matrix domain of the matrix are more general and more comprehensive than the corresponding consequences of matrix domain of.
MutS binding to ATP can already cause a closed clamp-like state, (i.e. perform the tilting movement) as shown by SAXS analysis (Hura et al., 2013b), but may possibly not change the conformation of the mismatched binding domain (Qiu et al., 2012), as consequence of the connector domain movement.
MutS binding to a non-hydrolysable ATP analog can already cause a closed clamp-like state, (i.e. perform the tilting movement) as supported by SAXS analysis (Hura et al., 2013b), but may possibly not change the conformation of the mismatched binding domain (Qiu et al., 2012), as consequence of the connector domain movement.
