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Embryologically, these occur as a consequence of disruption of the somitic mesoderm during gastrulation, somites during segmentation or sclerotomal precursors during the membranous phase.
Based on the overall in vitro and in vivo observations, we hypothesized that two distinct effects occur as a consequence of disruption of RARα function.
This continued uptake of serine indicates that the protein synthesis block was not a consequence of disruption in general amino acid uptake, possibly through minor perturbations in the VSG coat negatively affecting amino acid transporters.
Aneuploidy is most likely a consequence of disruption of meiosis during gametogenesis.
A lower ATP production might be a consequence of disruption of the inner mitochondrial transmembrane potential in mutant cells.
We propose that compensatory effects, as a consequence of disruption of the KKS, could dysregulate expression of inflammatory genes related to metabolic disorders such as insulin resistance.
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The changes in the number of neurons in different cortical regions could be a consequence of disruptions in PC proliferation, differentiation and/or neuronal migration.
In this case, the apparent loss of Fab-7 insulator activity would have to be an indirect consequence of disruptions in the functioning of the neighboring dCTCF-dependent insulators, Fab-6 and Fab-8.
For example, adolescent suicidal behavior often occurs in the context of family conflict, including strivings for autonomy, in the context of academic and disciplinary difficulties, and in the consequence of disruptions in peer relationships that are important as youths get older.
Indeed, he thinks that regulation has an important role in tempering some of the more traumatic consequences of disruption — especially in the sharing economy.-.
Determined efforts, acknowledging the interactions and interlinkages between energy and other sectors, are needed to avoid adverse consequences of disruption in energy supply.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com