However, we adopted a design to minimize the likelihood that predictors would be assessed following discontinuation or reinitiation events, thus avoiding the problem of predictors being consequences of discontinuation or reinitiation, rather than causes.
59 When comparing their results with ours, we find that prescribers' barriers are concordant with those of patients with respect to resistance to change, poor acceptance of non-drug alternatives, and fear of negative consequences of discontinuation.
There is also a need for greater public education on aspirin for primary prevention, including information on the risks of inappropriate aspirin use and the consequences of discontinuation [ 47].
However, two recent cross-sectional studies looking at barriers to discontinuation of benzodiazepines and antipsychotics in nursing homes reflected subthemes identified in our review fear of negative consequences of discontinuation such as poorer quality of life, symptom recurrence, greater workload and a lack of available, effective, non-drug alternatives.
Both treatment arms experienced increases in total cholesterol, LDL, and triglycerides at 6 months, but this could be perceived as a consequence of the discontinuation of tamoxifen.
Although trials of intermittent PrEP are underway, little is currently known about the efficacy of periodic or selective PrEP use, and the potential consequences of PrEP discontinuation or "holidays," as observed in the HAART literature.
Interestingly, the negative consequences of forced discontinuation of MMT have recently been hypothesized following the Russian occupation of Crimea and a resulting reversal in government policy previously supportive of MMT [ 33].
41 Given the consequence of early premature discontinuation and nonadherence, 10, 33 it is important to improve patient adherence to medication therapy and give long enough therapy to reduce relapse and hospitalization and costs.
Having suspended the first treatment as a consequence of adverse events reduced the probability of discontinuation of the second treatment by half (HR 0.54 (95% CI: 0.34 0.84)).
Rheumatologists should choose antiviral drugs according to guidelines and informing patients the serious consequences of antiviral drugs discontinuation at each interview.
