Sentence examples for consequence of deletion from inspiring English sources

The other five gene content haplotypes are all B haplotypes that lack some of the B-specific genes, either as a consequence of deletion (eg: cB02|tB01), or recombination that introduced either the centromeric (eg: cA01|tB01) or telomeric (eg: cB01|tA01) motif of the A haplotype.

Interestingly, we detected an upregulation of eIF5A2 as a consequence of deletion of Dohh.

In order to study the consequence of deletion of Ngn3 in the hypothalamus throughout development, mice that are homozygous for the floxed Ngn3 allele (Ngn3 flox/flox) were generated as previously described (Mellitzer et al., 2010).

We also examined the consequence of deletion of AR in macrophages on PCa development using a similar approach since our in vitro data demonstrated that AR silencing in THP-1 cells increased PCa cell migration and CCL2 expression (Fig 1B and D).

It is also notable that the critical figure in their paper that assesses the phenotypic consequence of deletion of the angiotensinogen gene (Agt -/- ; Figure 4) does not provide data for contemporaneous untreated Marfan mice – an essential control, but rather the angiotensinogen knockout Marfan mice are only compared to WT animals.

Saccharomyces cerevisiae diploid cells constantly exposed to rearrangement stress as a consequence of deletion of RAD52 (engaged in HR) or CTF18 (regulating PCNA and cohesion complex access to DNA) led to GCR, which can reduce the genome to the haploid level.

Collectively, our data provides direct evidence supporting the hypothesis that haploinsufficiency of multiple genes in the commonly deleted segment is the most likely relevant genetic consequence of deletions spanning chromosome 5q31.2.

Regions of extended homozygosity in the genome can also be a consequence of deletions along the genome.

11, 23 In addition to these (predominantly pediatric) aggressive neoplasms, which are defined by primary loss of SMARCB1 expression as a consequence of deletions or mutations involving the SMARCB1 locus, secondary SMARCB1 loss has been reported in carcinomas arising in different visceral organs including the gastrointestinal tract, 11 pancreas, 18 uterus, 19 and nervous system.

The use of Nestin-Cre control samples is therefore necessary to distinguish real consequences of deletion of the gene under investigation from side effects resulting from Nestin-Cre associated hypopituitarism.

To examine the possible consequences of deletion of 5'HS5 on ACH formation, we compared the 3D structures of the PAC1B and PACΔ1B transgenes in definitive erythroid cells isolated from 14.5 dpc fetal livers with the 3C technique (Fig. 3).