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Blebbing is the likely consequence of deficient Arp2/3 mediated actin polymerization at the cell cortex, since we observed the same blebbing phenotype in Arp2/3 depleted cells.
However, it is unlikely that the phenotype we observe in the absence of Shh signaling is a consequence of deficient Slit expression, as, in fact, mice deficient in Slit1 and Slit2 display the opposite phenotype: ventrally displaced ascending dopaminergic fibers, with a relative expansion of the medial fibers that course ventrally [3].
Thus, deficient object categorization might be a consequence of deficient association formation in schizophrenia.
The somatic mutations that affected the GCG repeat in this study are a consequence of deficient MMR function.
We additionally show that the defect in NK maturation is the consequence of deficient maturational cues provided by bone marrow stromal cells.
We also show that the defect in NK maturation is the consequence of deficient maturational cues provided by bone marrow stromal cells.
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This stimulus is recognized to mimic the ischemia-reperfusion consequences of deficient conversion of maternal spiral arteries, the underlying causes of the oxidative stress, which precipitates the symptoms of IUGR and PE.
The objective of the present study was to further investigate the pemetrexed hypersensitivity and DNA double strand break (DSB) formation observed in UNG−/− cells in order to better understand the consequences of deficient uracil excision during pemetrexed exposure.
Since all FA consequences are the result of deficient FXN expression, we explored whether dyclonine was able to induce FXN in FA patient cells and the animal model (Fig. 2).
For instance, Fe from fertilizers could be quickly oxidized and became insoluble in soil, so Fe deficiency is mainly a consequence of Fe deficient soils [9].
Since both effects are a consequence of the deficient vasculature, they may co-exist anyway.
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