Moreover, in studies of T cells and hematopoietic cells, we did not detect any reduction in apoptosis as a consequence of deficiencies of the genes for the individual family members.
Although, we agree that the observed mortality could be, in fact, a consequence of deficiencies in the several other cell compartments and may include crosstalk independent Nfkb2 functions.
The main interest of the mouse system is to exploit the recent generation of transgenic mice and to study the consequence of deficiencies, mutations and conditional expression of gene products.
The diverse effects of S1P make it difficult to dissect its role in different aspects of mammalian physiology and to predict the in vivo consequences of deficiency in S1P degrading enzymes, including S1PL.
In this study, the consequences of deficiency in any of these two metabolites were investigated by including mutants (cad2-1, vtc1-1 and cad2-1 vtc1-1) which demonstrated multiple genotype-specific effects (for a schematic overview, see Fig. 10).
To examine the consequence of Lpcat3 deficiency in vivo, we generated Lpcat3-deficient mice from targeted ES cells.
Beriberi is a consequence of thiamine deficiency.
The worst consequence of iodine deficiency isn't goiters, but malformation of fetuses' brains, so they have 10 to 15 points permanently shaved off their I.Q.'s.
Scurvy occurs as a consequence of a deficiency of vitamin C. Clinical manifestations include bone disease, irritability, and bleeding under the skin and mucous membranes.
The functional consequence of surfactant deficiency is poor lung volume at end expiration, with unfavorable pulmonary mechanics during inspiration.
