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In our studies, we examined the consequence of aggregation on superparamagnetic iron oxide (SPIO) nanoparticle-induced magnetic hyperthermia.
Lower drug release rates have been reported and are a consequence of aggregation of microspheres in the release media (Bain et al. 1999).
One consequence of aggregation, which we documented, is that it may be impossible to disperse the cells in tight aggregates without killing the cells.
In this way we minimized changes in gene expression that are a consequence of aggregation behavior (see Andersen et al., 2014).
It was known that prechondrogenic condensation results from cellular aggregation and differential mitosis, but increased cellular packing in the initiation step of condensation is a consequence of aggregation rather than mitosis.
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Instead of directly affecting aggregate formation, HSPA5 most likely compensates for downstream consequences of aggregation and thereby delays disease onset (Gorbatyuk et al., 2012).
The starting point for uncovering the origins of disease pathology must therefore be a thorough understanding of the general cell biological function of inclusions and their potential role in modulating the consequences of aggregation.
Isopods are an ideal model system for the study of these questions; however, surprisingly many gaps in our knowledge still remain and therefore we do not yet truly appreciate the extent of the consequences of aggregation for the physiology, behaviour, or evolution of species [12], [13].
As α-syn toxicity is generally considered a consequence of its aggregation, we verified that when TAT-α-syn had deleterious properties an aggregation pattern was detectable.
The loss of information content of terrain curvature as consequence of spatial aggregation was used to determine an amplification factor for soil hydraulic conductivity to compensate the resulting retardation of water flow.
The practical consequence of this aggregation may be observed as spurious results associated with receptor-based high throughput screening assays as well as anomalies in phase-solubility analysis encountered in the study of hydrophobic materials with cyclodextrins.
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