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In an interview, Khan said that public pressure for judges to impose harsher sentencing – however understandable the wellspring of outrage – could have the unintended consequence of affecting the sentences given to poor and minority defendants the most.
Conventional chemotherapeutic drugs suffer from a narrow therapeutic index as a consequence of affecting not only cancer cells but basically all cells with high proliferation rates.
Thus the effect on podosome assembly of altering DG expression levels either up or down was not a simple consequence of affecting Tks5 levels in the cell (Figure 5B,C) as Tks5 levels were equivalent in both knockdown and overexpressing cells.
The cancer-associated SNPs in the 5' region of TERT, most of the intergenic cancer-associated SNPs, and all the cancer-associated SNPs within CLPTM1L had surrogates with a likely functional consequence of affecting binding, indicated by a category 2 score (highlighted in Table 4 and Supplementary Table 3).
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Studies on consequences of affect on cognitive processing (cognitive bias) seem to provide proxy measures of the valence (positive/negative) of affective states.
Also, the occurrence of hypermutators among Argentinean CF patients was very high, with hypermutability being a consequence of mutations affecting the MRS genes (mostly the mutL gene, but also mutS).
We have recently shown that a significant proportion of isolated autosomal dominant PRS is the consequence of CRMs affecting the developmental expression of SOX9 (7, 39).
Consequently, reliance on a <7% threshold measure as the "quality standard" for public reporting or pay for performance could have the unintended consequence of adversely affecting patient safety.
Since the AzI content was increased significantly in JIMT-1 cells as early as 24 h of DFMO treatment, we decided to investigate whether this increase was a consequence of DFMO affecting the cell cycle progression.
Trans-splicing modulation of E10 splicing is independent of the specific mutation affecting splicing and can therefore have a general application for the correction of the downstream consequences of mutations affecting splicing regulatory elements.
Even this statistic understates the consequences of life affecting aortic regurgitation without re-intervention.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com