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The existence of these transcripts appears to be restricted to the bovine species and is probably the consequence of a modification in the transcriptional termination regulation.
Such downregulations could allow tamoxifen-resistant cells to escape cell death induced by the immune system (for example, cytotoxic T lymphocytes or natural killers cells), or these observations may be a consequence of a modification of the cellular microenvironment in the tamoxifen-resistant tumor samples.
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Histone modifications: Again, epigenetic regulation can be understood not as the consequence of a single modification (e.g., CpG methylation), but rather as the product of several epigenetic factors working in concert.
A widely recognized functional consequence of a UBL modification is ubiquitin-mediated proteolysis, although ubiquitin can be attached to targets via a variety of linkages that signal different effects on targets (2).
The consequence is a modification of the structure of the protein, by which its biochemical and antigen characteristics are changed.
Computer-based models and simulations are unlikely to ever be able to convey information about all possible potential consequences of a design modification.
The strong relaxation effects appear to be a consequence of cation modification, which results in a network of ionic crosslinks formed by multivalent cation sulfonate interactions.
PABA/NO treatment of HDMVEC resulted in a decrease of the high molecular weight band and in a consequent increase of eNOS monomer, perhaps as a consequence of sulfhydryl modification through S-nitrosylation or S-glutathionylation.
They point out that the pharmaceutical setting obtains an economic benefit as a consequence of prescription modification, for which the health system should be compensated.
As a consequence of these modifications, an increased recruitment of NF-κB to the promoter of several cytokines and chemokines could be observed [ 79].
This effect is due to a more negative net charge which is a consequence of covalent modification of the LDL amino groups by the phospholipid aldehyde.
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