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However, our observation that internalization properties of Cav3.2 channels were not affected by the presence of the calnexin C-tail strongly supports the notion that the increased channel surface expression is the direct consequence of a decreased ER retention of the channel upon uncoupling of Cav3.2 from calnexin.
Its up-regulation in consequence of a decreased Aβ42/Aβ40 ratio (whereas an increased ratio did not up-regulate PLAT) may contribute to enhanced fibrinolysis.
It can be speculated that upregulation of ACTA2 in consequence of a decreased Aβ42/Aβ40 ratio is a mechanism that might also occur in smooth muscle cells, which in turn could lead to improved vascularisation and could regulate blood pressure.
The fact that GAP43 was up-regulated in consequence of a decreased Aβ42/Aβ40 ratio, but not in response to an increased one, is in line with the aberrant GAP43 gene expression that has been observed in AD [23].
We did not find any significant difference in cardiac function between Ctrl and SM-Dicer KO mice, except for a slight decrease in wet weight and IVSW at 8 10 weeks, which is likely to be a consequence of a decreased cardiac after-load and not a cause of the decrease in blood pressure.
Syntaxin 3A was found to be inversely regulated: It was weakly up-regulated in consequence of an increased Aβ42/Aβ40 ratio (p = 0.159, fold change 1.4), whereas it was down-regulated in consequence of a decreased one (p = 0.00268, fold change = −3.7).
Similar(43)
The body mass loss of the subjects during Ramadan was not reported, but the authors considered that the majority of the loss was due to reductions in adipose tissue, as a consequence of a decrease in energy intake.
This enhancement is attributed to an increase in the platinum surface area as a consequence of a decrease in the platinum particle size.
The reduction of the effective dimensions of the structure will result in a shortening of the effective electron-impurity distance, with the consequence of a decrease in the energies of both states.
Therefore, we expected to see a decrease in pole-pole separation as a consequence of a decrease in forces acting on the poles from the cap.
This aneuploidy was attributed to increased meiosis I non-disjunction as a consequence of a decrease in the rates of recombination [23].
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com