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As a consequence, loss of peripheral tolerance ensues.
Polarization during cell growth by directed membrane trafficking is essential for cell division, therefore we hypothesized that GFP-AR149 expressing cells may exhibit retarded cell cycle progression and as a consequence loss of viability.
As a consequence, loss of DKK3 may promote hyperactivation of the PCP pathway, thereby potentially enhancing tumour aggressiveness.
As a consequence, loss of Giα proteins led to a defect in the activation of Akt and ERK1/2 by EGF and HB-EGF.
Probably as a consequence, loss of ULBP1 drivers, and even ULBP1 itself, had little detectable effect on the capacity of HAP1 cells to stimulate a response (data not shown).
This second "anaphase" steady state is also missing in cells that express nondegradable cyclin B and S1121A separase, and as a consequence, loss of tension caused by APC/C activation causes the system to revert to a prometaphase-like state.
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Hereditary breast carcinomas are predominantly a consequence of loss-of-function germline mutations in one of two major breast cancer susceptibility genes, BRCA1 and BRCA2 [8]–[10].
Whether oxidative DNA damage is a direct consequence of loss of NKX3.1 or a secondary consequence of PIN development is unknown.
"It is just a consequence of loss of manufacturing and recession and joblessness and decaying infrastructure.
I provide evidence that atrial septum reduction in plethodontid salamanders is a direct consequence of loss of these signaling interactions due to lung regression.
The development of urothelial malignancy is not solely a consequence of loss of proliferation constraints but also involves loss of cellular differentiation, defined histopathologically as grade.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com