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This accounts for the facilitation of spontaneous Ca2+ release events and delayed afterpotentials (DADs, their arrhythmogenic electrical consequence) induced by either INaL enhancement or CaMKIIδ overexpression [ 52] and suppressed in both cases by INaL blockade [ 25].
Chang and Pomeranz had revealed that relatively low doses of naloxone only block the analgesic effect induced by low-frequency (4 Hz) of electroacupuncture (EA) stimulation, but not the consequence induced by high-frequency (200 Hz) of EA [ 16], suggesting that the low-frequency, rather than the high-frequency, of EA increases the release of endogenous opioids.
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Despite considerable clinical success to date, there has been limited fundamental understanding of the biomechanical consequences induced by FPD treatment.
In fact, tests such as Vickers micro-indentation allowed to appreciate the effects of the graded compositional profile and the consequences induced by thermal treatments.
These processes might include efflux of the antibiotic via multidrug efflux pumps ( Nikaido 2009), built-in target (Criswell et al. 2006; Long et al. 2009) or antibiotic modifications or proteic systems that might counteract the detrimental consequences induced by the antibiotic such as the generation of oxidative stress etc. ( Hassett and Imlay 2007; Kohanski et al. 2007; Shin et al., 2011).
Apart from general debates about the desirable and undesirable features of the precautionary principle, challenges to it lie in its translation to social effects and social sustainability, as well as to its application to consequences induced by intentional actions of agents.
This powerful method is widely used to study biological consequences induced by the down-regulation of selected genes [1], [2], [3], [4].
The biological consequences induced by the retention of Intron 4, including the potential that this contributes to the protein sequence in this important regulatory Zn-finger protein, are presently unknown.
In addition, determining resource usage and consequences induced by the fire-related injury may be complicated.
However, this approach necessitates an evaluation of the consequences induced by Kv10.1 deletion.
To date, we have not identified any phenotypic consequences induced by the fusion proteins in normal urothelial cells.
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