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To evaluate whether the TGF-β1-stimulated JNK activation had a functional consequence in the expression of myofibroblast markers, we preincubated RMF-EG cells with SP600125, specific inhibitor of JNK, prior to TGF-β1 stimulus.
In a recent study we described age-related changes in the expression of the prolyl-4-hydroxylase domain (PHD) 3 and as a consequence in the expression of the hypoxia-inducible factor (HIF -1α transcription factor (KatscHIF -1α2006; Rohrbach etranscription
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The differences in affinity could have important consequences in the expression of sPLA2-V protein.
Several studies showed that gains (or losses) in DNA genomics have consequences in the expression levels of genes in the implicated regions, which are increases or decreased, respectively [ 264– 264].
As a consequence, perturbations in the expression of PRS genes may result in many unexpected cellular events, such as an abnormal increased chitin content and other cell wall alterations [ 33- 35].
In consequence, the expression of IP-10 in IEC has to be tightly regulated to prevent infections on the one hand and the development of pathological conditions like chronic intestinal inflammations on the other hand.
In consequence, the expression of the known CK isoforms is downregulated in these muscles.
In consequence, the expression of all tested genes, for all ages and mice types, was referenced to the expression levels observed in this group.
The defect may be a consequence of haploinsufficiency in the expression of a placental gene that resides on the X chromosome specifically in humans.
A current model suggests that persister cells are generated as a consequence of fluctuations in the expression levels of certain genes and that this noise can be amplified by external signals [ 11].
The reduced lignin observed in fpgs1 mutants might not only be due to reduced flux of methyl units to lignin precursors, but is also a consequence of changes in the expression of genes associated with lignin biosynthesis and cell wall remodeling.
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