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All participants gave informed consent to a protocol approved by the Institutional Review Board of Tohoku University School of Medicine.
All subjects gave informed consent to a protocol reviewed and approved by the Brandeis University Committee for the Protection of Human Subjects.
Healthy donor and patient sera were obtained following written consent to a protocol approved by the Committee for the Protection of Human Subjects at Dartmouth College.
All MARIBS participants had given informed consent to a protocol approved by the London Multicentre Research Ethics Committee (reference no. MREC98/2/38) and had specifically consented to their anonymised medical images from the study being used for teaching and research purposes.
All subjects provided written consent to a protocol approved by the ethical review boards of the two participating hospitals and the Comité Ético de Investigación Clínica de Aragón, CEICA, for AWHS subjects.
According to "Re-Engineering Clinical Trials: Best Practices for Streamlining the Development Process," which cites FDA data, nearly 10% of studies have issues related to patient consent, including unapproved forms, failure to obtain written informed consent, invalid consent documents and failures to re-consent to a revised protocol.
The CRC sample biobank used is described elsewhere.70 Briefly, tissue samples were obtained following patient's written informed consent according to a protocol approved by the Institutional Human Subject Review Board of the Centre Hospitalier Universitaire de Sherbrooke (CHUS; protocol 07-089).
The blood sample was obtained with written informed consent according to a protocol approved by the University of British Columbia Research Ethics Board.
All patients and normal subjects provided written informed consent according to a protocol used in the current study that was approved by the Johns Hopkins Institutional Review Board.
Tissues were obtained after patients' written informed consent, according to a protocol approved by the Institutional Human Subject Review Board of the Centre Hospitalier Universitaire de Sherbrooke.
All subjects gave informed consent according to a protocol approved by the Yale University Human Investigation Committee.
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