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Three hundred and ninety eight consented study subjects were recruited for the study.
Previous cross referencing studies have typically compared one or two electronic sources, such as coded hospital discharge diagnoses and cause of death, with case note review, 19 20 21 questionnaires to general practitioners, 22 or active case finding in a prospective consented study 1 23 24 (see supplementary table 1).
A total of 398 consented study patients were involved in this study.
Self-designed semi-structured questionnaire was also administered to each consented study participant for socio-demographic information.
A detailed self-designed semi-structured questionnaire was administered to each consented study participant for socio-demographic information including age, marital status, behavioural activities (exercise, smoking and alcohol consumption), educational background, income level, type of disability and occupation.
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Approximately 5 mL of fasting venous blood specimen was collected from each consenting study participant.
All consenting study participants have been linked to the National Health Service (NHS) central register since 1972.
Consenting study members (75 936 (89.1%)) were linked to National Health Service mortality data up to February 2008.
Self-administered and anonymous questionnaire was distributed to 220 eligible consenting study participants.
All persons consented to study participation.
Women bearing abnormal fetuses were not consented for study.
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